Comparative pathology of the diseases caused by Hendra and Nipah viruses

Microbes Infect. 2001 Apr;3(4):315-22. doi: 10.1016/s1286-4579(01)01385-5.


Information on the pathogenesis and transmissibility of Hendra and Nipah viruses was obtained by comparing their histopathology. Both viruses induced syncytial cells in vascular tissues and they were primarily vasotropic and/or neurotropic, generating interstitial pneumonia or encephalitis. Nipah virus in pigs was also epitheliotropic in respiratory epithelium and thus contagious.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Brain / pathology
  • Cytopathogenic Effect, Viral
  • Giant Cells
  • Humans
  • Immunohistochemistry
  • Lung / pathology
  • Paramyxoviridae Infections / pathology*
  • Paramyxoviridae Infections / transmission
  • Paramyxoviridae Infections / veterinary
  • Paramyxoviridae Infections / virology
  • Paramyxovirinae / pathogenicity*