Protein kinase C isoenzyme: selective expression pattern of protein kinase C-θ during mouse development

Mech Dev. 2001 May;103(1-2):197-200. doi: 10.1016/s0925-4773(01)00357-4.


Protein kinase C (PKC)-θ, a serine/threonine protein kinase and novel PKC subfamily member, has been recently identified as an essential component of the T cell synapse which activates the NF-kB signaling cascade leading to expression of the IL-2 gene during T cell activation. By RNA in situ hybridization to whole-body embryo sections it is shown that the murine PKCθ is specifically expressed in tissues with hematopoietic and lymphopoietic activity. Expression is also evident in skeletal muscle. A further highly specific expression was observed in the peripheral and central nervous system which is described in detail. Expression in the brain persists up to adult stages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / embryology
  • Cerebellum / embryology
  • DNA, Complementary / metabolism
  • Gene Expression*
  • Isoenzymes / biosynthesis*
  • Mice
  • Mice, Inbred C57BL
  • Protein Kinase C / biosynthesis*
  • Protein Kinase C-theta
  • Tissue Distribution


  • DNA, Complementary
  • Isoenzymes
  • Prkcq protein, mouse
  • Protein Kinase C
  • Protein Kinase C-theta