Candidate gene region 15q26 and genetic susceptibility to coeliac disease in Finnish families

Scand J Gastroenterol. 2001 Apr;36(4):372-4. doi: 10.1080/003655201300051153.


Background: Studies in the Irish and British populations have indicated that chromosome region 15q26 could include a novel non-HLA-linked locus conferring genetic susceptibility to coeliac disease. The locus is of particular interest, since a type I diabetes risk locus, IDDM3, maps to the same position. It was tested whether this locus shows evidence for genetic linkage to coeliac disease in Finland.

Methods: Ninety-nine Finnish families with at least one affected sibpair were studied. Five microsatellite markers mapped within approximately 20 cM region on chromosome 15q26 were typed. Non-parametric linkage (NPL) scores and allelic transmission (TDT) were studied.

Results: No evidence for genetic linkage could be obtained by the NPL scores calculated by the Genehunter program. However, transmission/disequilibrium analysis (TDT) revealed that haplotype D15S107*1-D15S120*6 was statistically significantly more frequently transmitted to affected than expected by chance (TDT chi2 9.0; P = 0.003). The subgroup of families having this haplotype, however, did not differ from the others, regarding to disease manifestation, HLA status, or geographical origin.

Conclusion: The 15q26 region appears not to be a major non-HLA susceptibility locus for gluten sensitivity in Finland, but a particular haplotype which may harbour a susceptibility gene was identified.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Celiac Disease / epidemiology*
  • Celiac Disease / genetics*
  • Chromosomes, Human, Pair 15*
  • Female
  • Finland / epidemiology
  • Genetic Linkage*
  • Genetic Predisposition to Disease / epidemiology*
  • Genetics, Population
  • HLA-DQ Antigens / genetics
  • Humans
  • Incidence
  • Male
  • Microsatellite Repeats
  • Population Surveillance
  • Probability
  • Sensitivity and Specificity


  • HLA-DQ Antigens