The Coffin-Lowry syndrome: an inherited faciodigital mental retardation syndrome

J Pediatr. 1975 May;86(5):724-31. doi: 10.1016/s0022-3476(75)80357-x.


Eight patients in three families had mental retardation, characteristic facies and hands, and skeletal changes; the clinical features suggested to us that they had a syndrome previously thought to represent two entities described by Lowry and associates and by Coffin and associates, respectively. New findings include skeletal, orodental, and dermatoglyphic abnormalities and histopathologic changes suggesting that the syndrome is a heritable disorder of connective tissue. Severe expression in males and transmission through mildly affected females suggest X-linked or sex-influenced autosomal dominant inheritance.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Bone Diseases, Developmental / genetics*
  • Child
  • Dermatoglyphics
  • Face* / abnormalities
  • Female
  • Funnel Chest / genetics
  • Hand Deformities, Congenital*
  • Humans
  • Hyperostosis Frontalis Interna / genetics
  • Hypertelorism / genetics
  • Intellectual Disability / genetics*
  • Kyphosis / genetics
  • Male
  • Pedigree
  • Scoliosis / genetics
  • Sternum / abnormalities
  • Syndrome
  • Toes / abnormalities