Citalopram: a comprehensive review

Expert Opin Pharmacother. 2001 Apr;2(4):681-98. doi: 10.1517/14656566.2.4.681.


Citalopram is a selective serotonin re-uptake inhibitor that has demonstrated antidepressant efficacy in numerous controlled clinical trials. Additional studies have shown that the drug benefits patients with other illnesses that are related in some way to serotonergic dysfunction, including anxiety, panic disorder, obsessive-compulsive disorder, premenstrual dysphoria, alcohol dependence and the behavioural disturbances of dementia. This paper reviews the full spectrum of citalopram's clinical efficacy, as well as its safety and tolerability, in a range of patients.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alcoholism / drug therapy
  • Antidepressive Agents, Second-Generation / therapeutic use*
  • Anxiety Disorders / drug therapy
  • Citalopram / adverse effects
  • Citalopram / pharmacokinetics
  • Citalopram / therapeutic use*
  • Clinical Trials as Topic
  • Dementia / drug therapy
  • Depression / drug therapy
  • Drug Interactions
  • Female
  • Humans
  • Premenstrual Syndrome / drug therapy
  • Serotonin Uptake Inhibitors / therapeutic use*


  • Antidepressive Agents, Second-Generation
  • Serotonin Uptake Inhibitors
  • Citalopram