Breast-feeding by a cyclosporine-treated mother

Obstet Gynecol. 2001 May;97(5 Pt 2):816-8.


Background: Cyclosporine is known to be excreted in breast milk, but levels in infants are not known. Post-transplant breast-feeding has been contraindicated in mothers treated with calcineurin inhibitors such as cyclosporine.

Case: A 35-year-old woman exclusively breast-fed her infant during the first 10.5 months of life while she was being treated with cyclosporine. Cyclosporine measurements in infant and maternal blood and breast milk revealed a mean breast milk/maternal blood level ratio of 84%, but undetectable levels in the infant. The infant grew and developed normally.

Conclusion: The infant of a cyclosporine-treated mother was breast-fed exclusively during the first 10.5 months of life and did not absorb a detectable amount of the drug. Fetal growth and development were normal.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Breast Feeding*
  • Cyclosporine / metabolism*
  • Cyclosporine / therapeutic use
  • Diabetes Mellitus, Type 1
  • Female
  • Humans
  • Immunosuppressive Agents / metabolism*
  • Immunosuppressive Agents / therapeutic use
  • Infant, Newborn
  • Kidney Failure, Chronic
  • Kidney Transplantation*
  • Male
  • Milk, Human / metabolism*
  • Pancreas Transplantation*
  • Postpartum Period
  • Pregnancy
  • Pregnancy Complications / therapy*


  • Immunosuppressive Agents
  • Cyclosporine