Data, design, and background knowledge in etiologic inference

Epidemiology. 2001 May;12(3):313-20. doi: 10.1097/00001648-200105000-00011.


I use two examples to demonstrate that an appropriate etiologic analysis of an epidemiologic study depends as much on study design and background subject-matter knowledge as on the data. The demonstration is facilitated by the use of causal graphs.

MeSH terms

  • Case-Control Studies
  • Cohort Studies
  • Data Collection
  • Endometrial Neoplasms / chemically induced
  • Epidemiologic Studies*
  • Female
  • Hormone Replacement Therapy / adverse effects
  • Humans
  • Postmenopause
  • Randomized Controlled Trials as Topic
  • Research Design
  • Statistics as Topic*