Expressions of spirituality by urban caregivers in African American families are the focus of the study discussed in this article. Data presented here were collected as part of a larger study that examined these caregivers' experience and meaning of caring as they influenced their capacity to care for people with stroke within their family systems. This study was executed within and supported the framework of systemic organization by Friedemann, according to which families as open systems strive for well-being. Spirituality, a component of well-being, is based on values concerning commitment, love, and affection. Eight themes concerning spirituality for all caregivers emerged from the data. Through spirituality, the caregivers felt well-being and were connected and comforted in difficult times related to caring.