pap genotype and P fimbrial expression in Escherichia coli causing bacteremic and nonbacteremic febrile urinary tract infection

Clin Infect Dis. 2001 Jun 1;32(11):1523-31. doi: 10.1086/320511. Epub 2001 Apr 30.


Escherichia coli strains from patients with febrile urinary tract infections (n=73) were examined for pap genotype and P fimbrial expression in relation to bacteremia and patients' background variables. Most isolates were pap(+) by DNA hybridization (n=51), and 36 were papG(IA2)(+) and 18 prsG(J96)(+) by polymerase chain reaction. The pap and papG genotypes of the infecting strain were shown to vary with host compromise, sex, and age. Bacteremia in noncompromised patients was caused by papG(IA2)(+) strains, but compromised hosts carried a mixture of papG(IA2)(+), prsG(J96)(+), and pap(-) strains. Women of all ages were infected with papG(IA2)(+) strains. Infected men carried prsG(J96)(+) or pap(-) strains and were older, and most had compromising conditions. papG(IA2)(+) strains predominated among patients with medical illness, whereas prsG(J96)(+) strains predominated among patients with urinary tract abnormalities. These findings emphasize the strong influence of host factors on the selection of E. coli strains causing febrile urinary tract infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesins, Bacterial / genetics
  • Adhesins, Escherichia coli / genetics*
  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Bacteremia / microbiology
  • Escherichia coli / genetics*
  • Escherichia coli Infections / microbiology
  • Female
  • Fever / microbiology
  • Fimbriae Proteins*
  • Fimbriae, Bacterial / genetics*
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Phenotype
  • Prospective Studies
  • Serotyping
  • Sex Factors
  • Urinary Tract Infections / microbiology*


  • Adhesins, Bacterial
  • Adhesins, Escherichia coli
  • PapG protein, E coli
  • fimH protein, E coli
  • Fimbriae Proteins