1,8-cineole protects against liver failure in an in-vivo murine model of endotoxemic shock

J Pharm Pharmacol. 2001 Apr;53(4):505-11. doi: 10.1211/0022357011775604.

Abstract

The effects of 1,8-cineole on D-galactosamine/lipopolysaccharide (GalN/LPS)-induced shock model of liver injury was investigated in mice. The co-administration of GalN (700 mg kg(-1), i.p.) and LPS (5 microg kg(-1), i.p.) greatly elevated serum concentrations of tumour necrosis factor-alpha (TNF-alpha), alanine aminotransferase and aspartate aminotransferase, and induced massive hepatic necrosis and lethality in 100% of control mice. Pretreatment with 1,8-cineole (400 mg kg(-1), p.o.) and dexamethasone (1 mg kg(-1), s.c.), 60 min before GalN/LPS, offered complete protection (100%) against the lethal shock and acute elevation in serum TNF-alpha and serum transaminases. Hepatic necrosis induced by GalN/LPS was also greatly reduced by both 1,8-cineole and dexamethasone treatment. The results indicate that 1,8-cineole protects mice against GalN/LPS-induced liver injury through the inhibition of TNF-alpha production, and suggest that 1,8-cineole may be a promising agent to combat septic-shock-associated pathologies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cyclohexanols*
  • Disease Models, Animal
  • Eucalyptol
  • Galactosamine / administration & dosage
  • Galactosamine / adverse effects
  • Lipopolysaccharides / administration & dosage
  • Lipopolysaccharides / adverse effects
  • Liver Failure / etiology
  • Liver Failure / prevention & control*
  • Male
  • Menthol / analogs & derivatives*
  • Menthol / pharmacology*
  • Mice
  • Monoterpenes*
  • Shock, Septic / complications
  • Shock, Septic / physiopathology*
  • Solvents / pharmacology*
  • Terpenes*
  • Transaminases / biosynthesis
  • Transaminases / metabolism
  • Tumor Necrosis Factor-alpha / biosynthesis

Substances

  • Cyclohexanols
  • Lipopolysaccharides
  • Monoterpenes
  • Solvents
  • Terpenes
  • Tumor Necrosis Factor-alpha
  • Menthol
  • Galactosamine
  • Transaminases
  • Eucalyptol