Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB

E Futai; T Kubo; H Sorimachi; K Suzuki; T Maeda

doi:10.1016/s0167-4781(00)00256-6

Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB

Biochim Biophys Acta. 2001 Jan 26;1517(2):316-9. doi: 10.1016/s0167-4781(00)00256-6.

Authors

E Futai¹, T Kubo, H Sorimachi, K Suzuki, T Maeda

Affiliation

¹ Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

PMID: 11342116
DOI: 10.1016/s0167-4781(00)00256-6

Abstract

A mammalian homologue of the Aspergillus atypical calpain PalB, PalBH, was identified and its cDNA sequences were determined in human and mouse. The PalBH mRNA was expressed nearly ubiquitously throughout mammalian tissues. When expressed in COS cells, PalBH was enriched in the nucleus, suggesting its role is distinct from that of conventional calpains.

Publication types

Comparative Study

MeSH terms

Amino Acid Sequence
Animals
Aspergillus / enzymology
Aspergillus / genetics
Base Sequence
Calpain / chemistry
Calpain / genetics*
Cloning, Molecular
Cysteine Endopeptidases / chemistry
Cysteine Endopeptidases / genetics
Fungal Proteins*
Humans
Mice
Molecular Sequence Data
Sequence Alignment
Sequence Homology, Amino Acid

Substances

Fungal Proteins
Calpain
Cysteine Endopeptidases
PalB protein, Aspergillus nidulans

Associated data

GENBANK/AB028639
GENBANK/AB028640