Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB

Biochim Biophys Acta. 2001 Jan 26;1517(2):316-9. doi: 10.1016/s0167-4781(00)00256-6.


A mammalian homologue of the Aspergillus atypical calpain PalB, PalBH, was identified and its cDNA sequences were determined in human and mouse. The PalBH mRNA was expressed nearly ubiquitously throughout mammalian tissues. When expressed in COS cells, PalBH was enriched in the nucleus, suggesting its role is distinct from that of conventional calpains.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Aspergillus / enzymology
  • Aspergillus / genetics
  • Base Sequence
  • Calpain / chemistry
  • Calpain / genetics*
  • Cloning, Molecular
  • Cysteine Endopeptidases / chemistry
  • Cysteine Endopeptidases / genetics
  • Fungal Proteins*
  • Humans
  • Mice
  • Molecular Sequence Data
  • Sequence Alignment
  • Sequence Homology, Amino Acid


  • Fungal Proteins
  • Calpain
  • Cysteine Endopeptidases
  • PalB protein, Aspergillus nidulans

Associated data

  • GENBANK/AB028639
  • GENBANK/AB028640