Corticosterone selectively attenuates 8-OH-DPAT-mediated hypothermia in mice

Int J Neuropsychopharmacol. 2001 Mar;4(1):1-8. doi: 10.1017/S1461145701002218.


The 5-HT1A agonist 8-OH-DPAT produces a hypothermia in mice mediated by somatodendritic 5-HT1A receptors, that is attenuated by antidepressants and corticosterone. The present study investigated if the effect of corticosterone is specific to the serotonergic system or a non-specific effect on thermoregulation. Administration of corticosterone for 3 d had no effect on dopaminergic (apomorphine) or adrenergic (clonidine) hypothermic challenges. However in addition to 8-OH-DPAT, nicotine-induced hypothermia was attenuated by corticosterone. Administration of the selective nicotinic antagonist mecamylamine had no effect on 8-OH-DPAT-induced hypothermia, although nicotine-induced hypothermia was attenuated by the selective 5-HT1A antagonist WAY-100635. This demonstrates a serotonergic-nicotinic interaction in the generation of hypothermia in mice and is consistent with corticosterone selectively attenuating somatodendritic 5-HT1A receptor function.

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin / antagonists & inhibitors
  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Body Temperature / drug effects*
  • Body Temperature / physiology
  • Corticosterone / pharmacology*
  • Hypothermia, Induced*
  • Mecamylamine / pharmacology
  • Mice
  • Mice, Inbred BALB C
  • Nicotine / pharmacology
  • Nicotinic Agonists / pharmacology
  • Nicotinic Antagonists / pharmacology
  • Piperazines / pharmacology
  • Pyridines / pharmacology
  • Receptors, Serotonin / drug effects*
  • Receptors, Serotonin / physiology
  • Receptors, Serotonin, 5-HT1
  • Serotonin Antagonists / pharmacology


  • Anti-Inflammatory Agents
  • Nicotinic Agonists
  • Nicotinic Antagonists
  • Piperazines
  • Pyridines
  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT1
  • Serotonin Antagonists
  • Mecamylamine
  • Nicotine
  • N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Corticosterone