Mediator complexes and transcription

Curr Opin Cell Biol. 2001 Jun;13(3):274-80. doi: 10.1016/s0955-0674(00)00209-x.

Abstract

Over the past decade, various components of the transcription machinery have been identified as potential targets for activators. Recently, metazoan versions of yeast Mediator have been isolated and found to act as key coactivators to many transcription factors. Recent work has defined the composition, function and biology of metazoan mediator complexes, which has led us to propose a new nomenclature for the variously named versions of the mediator complex.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / embryology
  • Drosophila / embryology
  • Embryo, Nonmammalian / embryology
  • Embryo, Nonmammalian / metabolism
  • Eukaryotic Cells / metabolism*
  • Humans
  • Macromolecular Substances
  • Mediator Complex
  • Nuclear Proteins / genetics
  • Nuclear Proteins / isolation & purification
  • Nuclear Proteins / physiology
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism
  • Trans-Activators / genetics
  • Trans-Activators / isolation & purification
  • Trans-Activators / physiology*
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism*
  • Transcription, Genetic / genetics
  • Transcription, Genetic / physiology*
  • Yeasts / metabolism

Substances

  • DRIP, VDR interacting protein complex
  • MED4 protein, human
  • Macromolecular Substances
  • Mediator Complex
  • Nuclear Proteins
  • Repressor Proteins
  • Trans-Activators
  • Transcription Factors