Pre-mRNA Splicing in the New Millennium

Curr Opin Cell Biol. 2001 Jun;13(3):302-9. doi: 10.1016/s0955-0674(00)00212-x.

Abstract

The past year has witnessed refinements in models of spliceosome assembly pathways and in the understanding of how splicing factors of the serine/arginine-rich (SR) protein family function. The role of splicing in human genetic diseases has also received a lot of attention recently as exonic splicing enhancers become better understood.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Therapy / methods
  • Genetic Variation / genetics
  • Humans
  • Models, Molecular
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • RNA Precursors / genetics
  • RNA Precursors / metabolism*
  • RNA Splice Sites / genetics
  • RNA Splice Sites / physiology*
  • RNA Splicing / genetics
  • RNA Splicing / physiology*
  • RNA-Binding Proteins
  • Serine-Arginine Splicing Factors
  • Spliceosomes / genetics
  • Spliceosomes / metabolism*

Substances

  • Nuclear Proteins
  • RNA Precursors
  • RNA Splice Sites
  • RNA-Binding Proteins
  • Serine-Arginine Splicing Factors