mRNA turnover

Curr Opin Cell Biol. 2001 Jun;13(3):320-5. doi: 10.1016/s0955-0674(00)00214-3.


Nuclear RNA-binding proteins can record pre-mRNA processing events in the structure of messenger ribonucleoprotein particles (mRNPs). During initial rounds of translation, the mature mRNP structure is established and is monitored by mRNA surveillance systems. Competition for the cap structure links translation and subsequent mRNA degradation, which may also involve multiple deadenylases.

Publication types

  • Review

MeSH terms

  • Alternative Splicing / physiology*
  • Animals
  • Peptide Chain Initiation, Translational / physiology
  • Protein Biosynthesis / physiology
  • RNA Precursors / metabolism*
  • RNA, Messenger / metabolism*
  • Ribonucleases / metabolism*
  • Ribonucleoproteins / metabolism*
  • Yeasts / metabolism


  • RNA Precursors
  • RNA, Messenger
  • Ribonucleoproteins
  • messenger ribonucleoprotein
  • Ribonucleases