Chromosome stability, DNA recombination and the BRCA2 tumour suppressor

Curr Opin Cell Biol. 2001 Jun;13(3):338-43. doi: 10.1016/s0955-0674(00)00217-9.

Abstract

The BRCA2 tumour suppressor works in DNA recombination and repair pathways to preserve genome integrity. Recent progress provides fresh insights into its role as a regulator of the Rad51 recombination protein, underpinning a model in which BRCA2's involvement in chromosome stability and tumour suppression arises from its participation in recombinational processes essential for DNA replication.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • BRCA2 Protein
  • Cell Transformation, Neoplastic / genetics*
  • Chromosome Aberrations / genetics
  • Chromosome Disorders
  • DNA Repair / genetics*
  • DNA Replication / genetics
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Gene Expression Regulation, Neoplastic / genetics
  • Gene Expression Regulation, Neoplastic / physiology*
  • Humans
  • Mitosis / genetics
  • Mitosis / physiology
  • Mutation / genetics
  • Neoplasm Proteins / genetics*
  • Neoplasm Proteins / metabolism*
  • Rad51 Recombinase
  • Recombination, Genetic / genetics
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism*
  • Transcription, Genetic / genetics
  • Transcription, Genetic / physiology

Substances

  • BRCA2 Protein
  • DNA-Binding Proteins
  • Neoplasm Proteins
  • Transcription Factors
  • RAD51 protein, human
  • Rad51 Recombinase