Membrane-bound transcription factors: regulated release by RIP or RUP

Curr Opin Cell Biol. 2001 Jun;13(3):344-8. doi: 10.1016/s0955-0674(00)00218-0.


Regulated nuclear transport of transcription factors from cytoplasmic pools is a major route by which eukaryotes control gene expression. Exquisite examples are transcription factors that are kept in a dormant state in the cytosol by membrane anchors; such proteins are released from membranes by proteolytic cleavage, which enables these transcription factors to enter the nucleus. Cleavage can be mediated either by regulated intramembrane proteolysis (RIP) catalysed by specific membrane-bound proteases or by regulated ubiquitin/proteasome-dependent processing (RUP). In both cases processing can be controlled by cues that originate at or in the vicinity of the membrane.

Publication types

  • Review

MeSH terms

  • Active Transport, Cell Nucleus / physiology
  • Animals
  • CCAAT-Enhancer-Binding Proteins / metabolism
  • Cell Nucleus / metabolism*
  • Cysteine Endopeptidases / metabolism
  • Cytoplasm / physiology
  • DNA-Binding Proteins / metabolism
  • Endopeptidases / metabolism*
  • Endoplasmic Reticulum / metabolism
  • Humans
  • Intracellular Membranes / metabolism*
  • Multienzyme Complexes / metabolism
  • Peptide Hydrolases / metabolism
  • Proteasome Endopeptidase Complex
  • Signal Transduction
  • Sterol Regulatory Element Binding Protein 1
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Ubiquitin Thiolesterase


  • CCAAT-Enhancer-Binding Proteins
  • DNA-Binding Proteins
  • Multienzyme Complexes
  • SREBF1 protein, human
  • Sterol Regulatory Element Binding Protein 1
  • Transcription Factors
  • USP16 protein, human
  • Endopeptidases
  • Peptide Hydrolases
  • Ubiquitin Thiolesterase
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex