The WWE domain: a common interaction module in protein ubiquitination and ADP ribosylation

Trends Biochem Sci. 2001 May;26(5):273-5. doi: 10.1016/s0968-0004(01)01787-x.

Abstract

Sequence profile analysis was used to detect a conserved globular domain in several proteins including deltex, Trip12 and poly-ADP-ribose polymerase homologs. It was named the WWE domain after its most conserved residues and is predicted to mediate specific protein-protein interactions in ubiquitin and ADP-ribose conjugation systems.

MeSH terms

  • ADP-Ribosylation Factors / chemistry*
  • Amino Acid Sequence
  • Animals
  • Conserved Sequence
  • Drosophila Proteins*
  • Humans
  • Insect Proteins / chemistry
  • Ligases / chemistry
  • Membrane Proteins*
  • Molecular Sequence Data
  • Poly(ADP-ribose) Polymerases / chemistry
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Software
  • Ubiquitin-Protein Ligases
  • Ubiquitins / metabolism*

Substances

  • DX protein, Drosophila
  • Drosophila Proteins
  • Insect Proteins
  • Membrane Proteins
  • Ubiquitins
  • Ubiquitin-Protein Ligases
  • Poly(ADP-ribose) Polymerases
  • ADP-Ribosylation Factors
  • Ligases