Glucose-sensing mechanisms in eukaryotic cells

Trends Biochem Sci. 2001 May;26(5):310-7. doi: 10.1016/s0968-0004(01)01805-9.


Glucose not only serves as a nutrient but also exerts many hormone-like regulatory effects in a wide variety of eukaryotic cell types. Recently, interest in identifying general mechanisms and principles used to sense the presence of glucose has significantly increased and promising advances have been made: in yeast, the first proteins with an apparently specific function in glucose detection have been discovered; in plant cells, there is increasing evidence for a diverse array of glucose-induced signalling mechanisms; and in mammals, glucose-sensing phenomena have turned out to be much more widespread than just in the well-known example of pancreatic beta cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cyclic AMP / metabolism
  • Eukaryotic Cells / metabolism*
  • Glucose / metabolism*
  • Hexokinase / metabolism
  • Humans
  • Islets of Langerhans / metabolism
  • Membrane Proteins / metabolism
  • Models, Biological
  • Monosaccharide Transport Proteins / metabolism
  • Plants / metabolism
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins*
  • Signal Transduction


  • Membrane Proteins
  • Monosaccharide Transport Proteins
  • RGT2 protein, S cerevisiae
  • SNF3 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Cyclic AMP
  • Hexokinase
  • Glucose