Space Shuttle Flight (STS-90) Enhances Degradation of Rat Myosin Heavy Chain in Association With Activation of Ubiquitin-Proteasome Pathway

FASEB J. 2001 May;15(7):1279-81. doi: 10.1096/fj.00-0629fje.

MeSH terms

  • Animals
  • Calpain / metabolism
  • Cathepsin L
  • Cathepsins / antagonists & inhibitors
  • Cathepsins / metabolism
  • Cysteine Endopeptidases / metabolism*
  • Cysteine Proteinase Inhibitors / pharmacology
  • Endopeptidases*
  • Enzyme Precursors / metabolism
  • Hindlimb Suspension
  • Leucine / analogs & derivatives*
  • Leucine / pharmacology
  • Ligases / metabolism
  • Models, Biological
  • Multienzyme Complexes / metabolism*
  • Muscle, Skeletal / metabolism*
  • Muscular Atrophy / physiopathology*
  • Myosin Heavy Chains / metabolism*
  • Proteasome Endopeptidase Complex
  • RNA, Messenger / metabolism
  • Rats
  • Reverse Transcriptase Polymerase Chain Reaction
  • Space Flight*
  • Ubiquitins / metabolism*
  • Weightlessness Simulation
  • Weightlessness*

Substances

  • Cysteine Proteinase Inhibitors
  • Enzyme Precursors
  • Multienzyme Complexes
  • RNA, Messenger
  • Ubiquitins
  • Cathepsins
  • Endopeptidases
  • Calpain
  • Cysteine Endopeptidases
  • Cathepsin L
  • Ctsl protein, rat
  • Proteasome Endopeptidase Complex
  • Myosin Heavy Chains
  • Ligases
  • Leucine
  • E 64