Role of Jak kinases and STATs in cytokine signal transduction

Int J Hematol. 2001 Apr;73(3):271-7. doi: 10.1007/BF02981951.

Abstract

The Janus family tyrosine kinase-signal transducer and activator of transcription (Jak-STAT) signaling pathway is broadly used by interferons and type I cytokines. These cytokines and interferons activate Janus family tyrosine kinases (Jak kinases), which in turn phosphorylate and thereby activate STAT proteins. Before activation, STAT proteins are cytosolic proteins; after activation, however, they are translocated to the nucleus where they function as transcription factors. This review summarizes salient features of the Jak-STAT pathway and focuses on the functional role of the different Jak kinases and STATs in vivo.

Publication types

  • Review

MeSH terms

  • Active Transport, Cell Nucleus
  • Animals
  • Cell Transformation, Neoplastic
  • Cytokines / physiology*
  • Cytosol / metabolism
  • DNA-Binding Proteins / physiology
  • Dimerization
  • Enzyme Activation
  • Gene Expression Regulation / physiology
  • Humans
  • Interferons / physiology
  • Janus Kinase 1
  • Janus Kinase 2
  • Janus Kinase 3
  • Milk Proteins*
  • Phosphorylation
  • Protein Conformation
  • Protein Processing, Post-Translational
  • Protein-Tyrosine Kinases / physiology*
  • Proto-Oncogene Proteins*
  • Receptors, Cytokine / physiology
  • STAT1 Transcription Factor
  • STAT2 Transcription Factor
  • STAT3 Transcription Factor
  • STAT4 Transcription Factor
  • STAT5 Transcription Factor
  • STAT6 Transcription Factor
  • Signal Transduction / physiology*
  • Trans-Activators / physiology
  • Transcription Factors / physiology*

Substances

  • Cytokines
  • DNA-Binding Proteins
  • Milk Proteins
  • Proto-Oncogene Proteins
  • Receptors, Cytokine
  • STAT1 Transcription Factor
  • STAT1 protein, human
  • STAT2 Transcription Factor
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • STAT4 Transcription Factor
  • STAT4 protein, human
  • STAT5 Transcription Factor
  • STAT6 Transcription Factor
  • STAT6 protein, human
  • Trans-Activators
  • Transcription Factors
  • Interferons
  • Protein-Tyrosine Kinases
  • JAK1 protein, human
  • JAK2 protein, human
  • JAK3 protein, human
  • Janus Kinase 1
  • Janus Kinase 2
  • Janus Kinase 3