A Mild Anionic Method for Generating O-Quinone Methides: Facile Preparations of Ortho-Functionalized Phenols

J Org Chem. 2001 May 18;66(10):3435-41. doi: 10.1021/jo001752e.


A low-temperature method for generating o-quinone methides is described which permits facile introduction of assorted R substituents onto the aryl ring system at low temperature. The method is useful for the efficient preparation of ortho-ring-alkylated phenols.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alkylating Agents
  • Biological Factors / chemical synthesis
  • Combinatorial Chemistry Techniques
  • Phenols / chemical synthesis
  • Quinones / chemical synthesis*


  • Alkylating Agents
  • Biological Factors
  • Phenols
  • Quinones