Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 3 (8), 1113-6

Nitrate Esters as Nitric Oxide Donors: SS-nitrates

Affiliations

Nitrate Esters as Nitric Oxide Donors: SS-nitrates

S I Zavorin et al. Org Lett.

Abstract

[structure: see text]. The important biological secondary messenger NO can be generated from exogenous nitrovasodilators and NO donors. Nitrate esters are nitrovasodilators and NO mimetics, believed to be biotransformed to NO in vivo. On the basis of a mechanistic hypothesis, nitrates have been synthesized that release NO at significant rates in neutral aqueous solution in the presence only of added thiol. The novel masked beta-mercaptonitrates reported (SS-nitrates), provide information on possible sulfhydryl-dependent biotransformation mechanisms for nitrates in clinical use.

Similar articles

See all similar articles

Cited by 1 article

Publication types

LinkOut - more resources

Feedback