Transmembrane ion conductance by an acyclic bolaamphiphile

Org Lett. 2001 May 3;3(9):1335-7. doi: 10.1021/ol015713g.

Abstract

[reaction in text] An acyclic bolaamphiphile forms ion channels in vesicles and planar bilayer membranes that are closely similar to the channels formed by related bismacrocyclic compounds. Thus the function of these ion channels does not depend on synthetically difficult macrocyclic subunits.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Transport
  • Ion Channels / chemistry*
  • Ion Channels / metabolism
  • Lipid Bilayers / chemistry*
  • Magnetic Resonance Spectroscopy
  • Membranes / chemistry*
  • Membranes / metabolism
  • Models, Molecular
  • Molecular Structure
  • Phosphatidylcholines / chemistry
  • Structure-Activity Relationship
  • Surface-Active Agents / chemistry

Substances

  • Ion Channels
  • Lipid Bilayers
  • Phosphatidylcholines
  • Surface-Active Agents
  • 1,2-diphytanoylphosphatidylcholine