Total synthesis of (-)-ratjadone

D R Williams; D C Ihle; S V Plummer

doi:10.1021/ol015753k

Total synthesis of (-)-ratjadone

Org Lett. 2001 May 3;3(9):1383-6. doi: 10.1021/ol015753k.

Authors

D R Williams¹, D C Ihle, S V Plummer

Affiliation

¹ Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405-7102, USA. williamd@indiana.edu

PMID: 11348240
DOI: 10.1021/ol015753k

Abstract

[reaction in text] A convergent asymmetric synthesis of (-)-ratjadone (1) has been achieved, confirming the assignments of stereochemistry for the naturally occurring antifungal metabolite.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Antifungal Agents / chemical synthesis*
Catalysis
Magnetic Resonance Spectroscopy
Molecular Structure
Pyrones / chemical synthesis*
Stereoisomerism
Structure-Activity Relationship

Substances

Antifungal Agents
Pyrones
ratjadone

Grants and funding

GM-42897/GM/NIGMS NIH HHS/United States