Abstract
Bacillus firmus, a non-pathogenic Gram positive (G+) bacterium of the external environment was investigated for immunomodulatory properties. It stimulated an increase in anti-ovalbumin IgG in sera, bronchoalveolar lavages and intestinal washings after both intranasal (i.n.) and intratracheal (i.t.) immunisation, and enhanced anti-ovalbumin IgA in intestinal secretions and in bronchoalveolar lavage fluid after i.n. or i.t. immunisation, respectively. The immunomodulatory effect of B. firmus on antibody formation was antigen specific.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adjuvants, Immunologic*
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Administration, Intranasal
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Animals
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Antibodies / immunology*
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Antibodies, Bacterial / blood
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Antibody Formation
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Antigens / immunology
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Bacillus / immunology*
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Bronchoalveolar Lavage Fluid / immunology
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Female
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Immunity, Mucosal* / immunology
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Injections
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Intestinal Mucosa / immunology*
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Intestines / immunology
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Mice
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Mice, Inbred BALB C
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Ovalbumin / immunology
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Respiratory Mucosa / immunology*
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Trachea
Substances
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Adjuvants, Immunologic
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Antibodies
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Antibodies, Bacterial
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Antigens
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Ovalbumin