Impact of early high caloric duodenal feeding on the oxygen balance of the splanchnic region after severe burn injury

Burns. 2001 Jun;27(4):389-93. doi: 10.1016/s0305-4179(00)00134-0.


Early enteral nutrition is recommended in burned patients. Depending on the amount administered, enteral feeding causes an increase of intestinal oxygen-demand. Although early moderate enteral nutrition has been shown to be beneficial, early high calorie enteral nutrition might lead to an imbalance of the O(2)-balance of the gut since intestinal perfusion is decreased after major burns. In 20 severely burned patients during the first 48 h of early high caloric duodenal feeding an assessment of the CO(2)-gap between the arterial and the gastric CO(2), as parameter for the intestinal O(2)-balance, was performed. Time points were prior to starting the enteral nutrition (BASE) subsequently every 30 min after increasing the amount of nutrition administered and from the 11th to the 48th h after beginning of nutrition in intervals of 6 h. In none of the patients was the CO(2)-gap increased during the rapid increase of enteral nutrition. On the contrary the CO(2)-gap decreased significantly. We conclude that high caloric duodenal feeding in the early hypodynamic postburn phase does not have adverse effects on the oxygen balance of the intestine.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Burns / therapy*
  • Carbon Dioxide / metabolism
  • Energy Intake*
  • Enteral Nutrition*
  • Female
  • Food, Formulated* / adverse effects
  • Humans
  • Intestinal Mucosa / metabolism*
  • Intubation, Gastrointestinal
  • Male
  • Middle Aged
  • Oxygen / metabolism*


  • Carbon Dioxide
  • Oxygen