Perinatal outcomes in gestational diabetes: a comparison of criteria for diagnosis

Am J Obstet Gynecol. 2001 May;184(6):1118-21. doi: 10.1067/mob.2001.114918.


Objective: The purpose of this study was to compare the perinatal outcomes of women after diagnosis of gestational diabetes by the current American College of Obstetricians and Gynecologists-National Diabetes Data Group recommendations with outcomes after diagnosis by the American Diabetes Association criteria.

Study design: We identified records of 242 women who had had the standard 3-hour oral glucose tolerance test between 1995 and 1999 at the Regional Medical center in Memphis. Patients were categorized into 1 of 3 groups as follows: euglycemic control subjects (n = 69), subjects with gestational diabetes diagnosed by the National Diabetes Data Group criteria (n = 130), and subjects with gestational diabetes diagnosed by the American Diabetes Association criteria (n = 43). Maternal and infant charts were reviewed. Primary outcomes included frequency of cesarean delivery, preeclampsia, and macrosomia. In univariate analysis the chi2 test was used to compare group differences, and in multivariate analysis we used stepwise logistic regression and controlled for confounding factors.

Results: No differences existed among the 3 groups regarding maternal race, body mass index, history of preeclampsia, or family history of diabetes. The frequency of overall cesarean delivery, of cesarean delivery for macrosomia or arrest disorder, of preeclampsia, and of macrosomia did not differ significantly among the 3 groups. Neonatal hypoglycemia was more frequent in the groups with a diagnosis by the American Diabetes Association criteria (23.3%) and by the National Diabetes Data Group criteria (16.2%) than in the control subjects (7.2%), reaching near significance (P =.057). In the multivariate analysis, cesarean delivery for macrosomia or an arrest disorder correlated negatively with parity and positively with body mass index. Preeclampsia was associated with African American race and body mass index; macrosomia correlated with a history of macrosomia and familial diabetes. Neonatal hypoglycemia was more common in the American Diabetes Association group (odds ratio, 2.45; 95% confidence interval, 1.004-5.97) and in the insulin-requiring National Diabetes Data Group category (odds ratio, 3.71; 95% confidence interval, 1.20-11.44).

Conclusion: The benefits of defining an additional high-risk population of women with gestational diabetes by the American Diabetes Association criteria are unclear. Further large-scale prospective clinical trials are required.

Publication types

  • Comparative Study

MeSH terms

  • Cesarean Section / statistics & numerical data
  • Diabetes Mellitus
  • Diabetes, Gestational / diagnosis*
  • Diabetes, Gestational / physiopathology*
  • Diagnostic Techniques, Obstetrical and Gynecological
  • Endocrinology
  • Female
  • Fetal Macrosomia / epidemiology
  • Humans
  • Hypoglycemia / epidemiology
  • Incidence
  • Infant, Newborn
  • Infant, Newborn, Diseases / epidemiology
  • Multivariate Analysis
  • Practice Guidelines as Topic
  • Pregnancy
  • Pregnancy Outcome*
  • Societies, Medical
  • United States