Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat

Clin Exp Hypertens. 2001 May;23(4):329-43. doi: 10.1081/ceh-100102671.


The hypotensive effects of the water extract of Marrubium vulgare L. and Foeniculum vulgare L. were investigated in spontaneously hypertensive rats (SHR) and in normotensive Wistar-Kyoto rats (WKY). Oral administration of Marrubium or Foeniculum extract lowered the systolic blood pressure of SHR but not of WKY. In SHR, Foeniculum but not Marrubium treatment increased water, sodium and potassium excretion. Ex vivo as well as in vitro, Marrubium extract inhibited the contractile responses of rat aorta to noradrenaline and to KCl (100 mM). Inhibition was greater in aorta from SHR compared to WKY and was not affected by the NO synthase inhibitor N-nitro-L-arginine. Vascular effects of Foeniculum extract were less pronounced than those of Marrubium and were blocked by N-nitro-L-arginine. These results indicate that hypotensive activity of Marrubium and Foeniculum extracts seems to be mediated through different pathways: Foeniculum appeared to act mainly as a diuretic and a natriuretic while Marrubium displayed vascular relaxant activity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antihypertensive Agents / pharmacology*
  • Aorta / drug effects
  • Aorta / physiopathology
  • Blood Pressure / drug effects*
  • Hypertension / drug therapy
  • Hypertension / physiopathology
  • Kidney / drug effects
  • Kidney / physiopathology
  • Lamiaceae*
  • Muscle Contraction / drug effects
  • Norepinephrine
  • Plant Extracts / pharmacology
  • Plants, Medicinal*
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • Urodynamics / drug effects
  • Vasoconstrictor Agents


  • Antihypertensive Agents
  • Plant Extracts
  • Vasoconstrictor Agents
  • Norepinephrine