Endoscopic duodenitis, gastric metaplasia and Helicobacter pylori

J Gastroenterol Hepatol. 2001 May;16(5):513-8. doi: 10.1046/j.1440-1746.2001.02482.x.


Background and aims: The purpose of this study was to investigate the relationship between gastric metaplasia and Helicobacter pylori in patients with endoscopic duodenitis.

Methods: The subjects were 57 patients with endoscopic duodentitis with or without H. pylori-associated gastritis. Biopsy specimens were obtained from the stomach and duodenal bulb to assess the histological findings and H. pylori infection. Gastric metaplasia was divided into three types: complete, intermediate and incomplete, according to the amount of mucus in the metaplastic cells. In 10 H. pylori-positive patients, endoscopic and histological findings of duodenitis were compared before and after eradication of the bacteria.

Results: There was no significant difference in the extent of gastric metaplasia or the appearance and severity of endoscopic duodenitis between H. pylori-positive and -negative groups. The complete type of gastric metaplasia was frequently detected in the H. pylori-negative group, whereas the incomplete type was frequently observed in the H. pylori-positive group. After eradication of H. pylori, the incomplete type changed to the complete type with a decrease of histological inflammation.

Conclusions: The complete type of gastric metaplasia occurred frequently without H. pylori infection, whereas the incomplete type was frequently associated with H. pylori infection.

MeSH terms

  • Adult
  • Aged
  • Duodenitis / microbiology
  • Duodenitis / pathology*
  • Duodenum / pathology
  • Endoscopy, Gastrointestinal*
  • Female
  • Gastric Mucosa / pathology*
  • Helicobacter Infections / complications
  • Helicobacter Infections / pathology*
  • Helicobacter pylori*
  • Humans
  • Male
  • Metaplasia
  • Middle Aged