Regulation of flowering in Arabidopsis by an FLC homologue

Plant Physiol. 2001 May;126(1):122-32. doi: 10.1104/pp.126.1.122.


The Arabidopsis FLC gene encodes a MADS domain protein that acts as a repressor of flowering. Late-flowering vernalization-responsive ecotypes and mutants have high steady-state levels of FLC transcript, which decrease during the promotion of flowering by vernalization. Therefore, FLC has a central role in regulating the response to vernalization. We have isolated an Arabidopsis gene, MAF1, which encodes a protein that is closely related to FLC. Overexpression studies demonstrate that MAF1 produces comparable effects to FLC, and likely has a similar function in the regulation of flowering. In contrast to FLC, however, MAF1 expression shows a less clear correlation with the vernalization response. In addition, MAF1 overexpression does not influence FLC transcript levels. Thus, MAF1 likely acts downstream or independently of FLC transcription. We further report identification of a cluster of four additional FLC-like genes in the Arabidopsis genome.

MeSH terms

  • Amino Acid Sequence
  • Arabidopsis / genetics
  • Arabidopsis / physiology*
  • Base Sequence
  • DNA Primers
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • MADS Domain Proteins
  • Molecular Sequence Data
  • Phylogeny
  • Plant Proteins
  • Sequence Homology, Amino Acid
  • Transcription Factors / chemistry
  • Transcription Factors / genetics
  • Transcription Factors / physiology*


  • DNA Primers
  • DNA-Binding Proteins
  • MADS Domain Proteins
  • Plant Proteins
  • Transcription Factors