The synthesis of Rantes, G-CSF, IL-4, IL-5, IL-6, IL-12 and IL-13 in human whole-blood cultures is modulated by an extract from Eleutherococcus senticosus L. roots

Phytother Res. 2001 May;15(3):268-70. doi: 10.1002/ptr.746.


An ethanol extract derived from the roots of Eleutherococcus senticosus was found to influence markedly the cytokine synthesis of activated whole blood cultures of ten healthy volunteers. Whereas the synthesis of Rantes was increased over a wide range of concentrations, the release of IL-4, IL-5 and IL-12 was significantly inhibited. An inhibition at higher concentrations, switching to a stimulation at lower doses of the extract was seen with G-CSF, IL-6 and IL-13. From these particular immuno-pharmacological effects of Eleutherococcus senticosus we suggest this herbal preparation possesses immuno-modulatory potency, rather than just being immuno-suppressive or -stimulating.

MeSH terms

  • Adult
  • Chemokine CCL5 / biosynthesis
  • Chemokine CCL5 / blood
  • Eleutherococcus
  • Female
  • Granulocyte Colony-Stimulating Factor / biosynthesis*
  • Granulocyte Colony-Stimulating Factor / blood
  • Humans
  • Immune System / drug effects*
  • Interleukin-12 / biosynthesis*
  • Interleukin-12 / blood
  • Interleukin-6 / biosynthesis*
  • Interleukin-6 / blood
  • Interleukins / biosynthesis
  • Interleukins / blood
  • Male
  • Middle Aged
  • Plant Extracts* / pharmacology
  • Plant Roots
  • Plants, Medicinal*


  • Chemokine CCL5
  • Interleukin-6
  • Interleukins
  • Plant Extracts
  • Granulocyte Colony-Stimulating Factor
  • Interleukin-12