Experimental modification of P50 suppression

Psychophysiology. 2001 May;38(3):531-9. doi: 10.1017/s0048577201981454.


White and Yee (1997) found that normal suppression of the P50 component of the event-related potential was disrupted during a paired-click paradigm when nonpsychiatric subjects performed mental arithmetic (MA) problems aloud, concurrently with the presentation of auditory stimuli. In fact, the degree of disruption reflected in the P50 suppression ratio fell within the range that is typically observed in schizophrenia patients. The present study was conducted to clarify the processes that might underlie the apparent disruption of P50 suppression during performance of an oral MA task. Participants completed a series of tasks designed to examine the impact of competing cognitive activity, competing auditory stimulation, muscle activity, and acute psychological stress on P50 amplitude and P50 suppression. Results suggested that psychological stress and heightened facial muscle activity may exert modulatory effects on P50 suppression.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acoustic Stimulation
  • Adolescent
  • Adult
  • Electroencephalography*
  • Evoked Potentials / physiology*
  • Female
  • Humans
  • Male
  • Schizophrenia / physiopathology