Unravelling the significance of cellular fatty acid-binding proteins

Curr Opin Lipidol. 2001 Jun;12(3):267-74. doi: 10.1097/00041433-200106000-00005.

Abstract

Cellular long-chain fatty acid (FA) transport and metabolism are believed to be regulated by membrane-associated and soluble proteins that bind and transport FAs. Several different classes of membrane proteins have been proposed as FA acceptors or transmembrane FA transporters. New evidence from in-vitro and whole-animal studies supports the existence of protein-mediated transmembrane transport of FAs, which is likely to coexist with passive diffusional uptake. The trafficking of FAs by intracellular fatty acid-binding proteins may involve their interaction with specific membrane or protein targets. Evidence is also emerging for concerted actions between the membrane and cytoplasmic fatty acid-binding proteins that allow for efficient regulation of FA transport and metabolism.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Transport
  • CD36 Antigens / metabolism
  • Carrier Proteins / metabolism*
  • Cell Differentiation
  • Cell Division
  • Cell Membrane / metabolism
  • Diffusion
  • Fatty Acid-Binding Protein 7
  • Fatty Acid-Binding Proteins
  • Fatty Acids / metabolism*
  • Humans
  • Models, Biological
  • Neoplasm Proteins*
  • Tumor Suppressor Proteins*

Substances

  • CD36 Antigens
  • Carrier Proteins
  • FABP7 protein, human
  • Fatty Acid-Binding Protein 7
  • Fatty Acid-Binding Proteins
  • Fatty Acids
  • Neoplasm Proteins
  • Tumor Suppressor Proteins