Biochemical characterization of human DNA polymerase iota provides clues to its biological function

Biochem Soc Trans. 2001 May;29(Pt 2):183-7. doi: 10.1042/0300-5127:0290183.


The human RAD30B gene has recently been shown to encode a novel DNA polymerase, DNA polymerase iota (poliota). The role of poliota within the cell is presently unknown, and the only clues to its cellular function come from its biochemical characterization in vitro. The aim of this short review is, therefore, to summarize the known enzymic activities of poliota and to speculate as to how these biochemical properties might relate to its in vivo function.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Base Pair Mismatch / genetics
  • Base Sequence
  • DNA Damage / genetics
  • DNA Polymerase I / metabolism
  • DNA Polymerase iota
  • DNA Repair / genetics
  • DNA Replication
  • DNA-Directed DNA Polymerase / chemistry*
  • DNA-Directed DNA Polymerase / metabolism*
  • Humans


  • DNA Polymerase I
  • DNA-Directed DNA Polymerase
  • DNA Polymerase iota
  • POLI protein, human