New advances in the understanding of the role of steroids and steroid receptors in disease

Biochem Soc Trans. 2001 May;29(Pt 2):205-9. doi: 10.1042/0300-5127:0290205.


Steroids and related compounds are important in disease development and prevention, via steroid receptor-mediated and receptor-independent mechanisms. Interaction of endogenous oestrogens with the oestrogen receptor has unfortunate mitogenic effects in breast cancer. However, dietary consumption of non-steroidal weak oestrogens, such as the soy isoflavone phytoestrogens genistein and diadzein, is associated with a decreased breast cancer risk. This may arise in part from the suboptimal configuration induced in the transactivation helix of oestrogen receptor-beta.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease*
  • Estrogens / metabolism
  • Humans
  • Oxytocin / metabolism
  • Receptors, Androgen / metabolism
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Receptors, Estrogen / metabolism
  • Receptors, Oxytocin / metabolism
  • Receptors, Steroid / metabolism*
  • Receptors, Thyroid Hormone / metabolism
  • Steroids / metabolism*
  • Transcription Factors / metabolism


  • Estrogens
  • Receptors, Androgen
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Estrogen
  • Receptors, Oxytocin
  • Receptors, Steroid
  • Receptors, Thyroid Hormone
  • Steroids
  • Transcription Factors
  • Oxytocin