Carnitine palmitoyl transferase I and the control of myocardial beta-oxidation flux

Biochem Soc Trans. 2001 May;29(Pt 2):245-50. doi: 10.1042/0300-5127:0290245.

Abstract

Carnitine palmitoyltransferase I is assumed to be rate limiting for beta-oxidation in all tissues. However, the concentration of malonyl-CoA in heart and muscle is high and is enough to completely inhibit beta-oxidation if this assumption is correct. In this review, we consider whether: (i) there is a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity; (ii) the measured malonyl-CoA concentration in the heart is physiologically meaningful; and (iii) carnitine palmitoyltransferase I is rate-limiting for beta-oxidation in the heart.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetyl Coenzyme A / metabolism
  • Animals
  • Biological Transport
  • Carnitine O-Palmitoyltransferase / chemistry
  • Carnitine O-Palmitoyltransferase / genetics
  • Carnitine O-Palmitoyltransferase / metabolism*
  • Humans
  • Isoenzymes / chemistry
  • Isoenzymes / genetics
  • Isoenzymes / metabolism
  • Kinetics
  • Malonyl Coenzyme A / metabolism
  • Mitochondria, Heart / enzymology
  • Mitochondria, Heart / metabolism
  • Myocardium / cytology
  • Myocardium / enzymology*
  • Myocardium / metabolism*
  • Oxidation-Reduction

Substances

  • Isoenzymes
  • Malonyl Coenzyme A
  • Acetyl Coenzyme A
  • Carnitine O-Palmitoyltransferase