Activity and postantibiotic effect of marbofloxacin, enrofloxacin, difloxacin and ciprofloxacin against feline Bordetella bronchiseptica isolates

Vet Microbiol. 2001 Jul 3;81(1):79-84. doi: 10.1016/s0378-1135(01)00349-2.

Abstract

The minimum inhibitory concentration (MIC) and postantibiotic effect (PAE) of marbofloxacin, enrofloxacin, difloxacin and ciprofloxacin were evaluated in vitro against 43 feline-source Bordetella bronchiseptica strains. All strains tested were susceptible to marbofloxacin and enrofloxacin (MIC90 0.5mg/l), while 93 and 84% of the strains were susceptible, respectively, to ciprofloxacin and difloxacin with MIC(90) values of, respectively, 1 and 8mg/l. The PAE was studied in 10 strains by exposure of bacteria to marbofloxacin, enrofloxacin, difloxacin and ciprofloxacin at 5 and 10 times minimum inhibitory concentration (MIC) for 1 and 2h. Regrowth was determined by measuring the viable counts after drug removal by a 10(3) dilution procedure. PAEs increased as a function of concentration and exposure time. The mean duration of PAEs varied between 1.1 and 8.2h, showing the following order: marbofloxacin>enrofloxacin>ciprofloxacin>difloxacin. These data are encouraging since fluoroquinolones have a possible role in the clinical treatment of B. bronchiseptica infections, and the strong PAE caused by quinolones may contribute to the in vivo efficacy of these drugs.

Publication types

  • Clinical Trial

MeSH terms

  • Animals
  • Anti-Infective Agents / pharmacology*
  • Anti-Infective Agents / therapeutic use
  • Bordetella Infections / drug therapy
  • Bordetella Infections / microbiology
  • Bordetella Infections / veterinary
  • Bordetella bronchiseptica / drug effects*
  • Cat Diseases / drug therapy
  • Cat Diseases / microbiology
  • Cats
  • Ciprofloxacin / analogs & derivatives*
  • Ciprofloxacin / pharmacology*
  • Ciprofloxacin / therapeutic use
  • Enrofloxacin
  • Female
  • Fluoroquinolones*
  • Male
  • Microbial Sensitivity Tests / veterinary
  • Quinolones / pharmacology*
  • Quinolones / therapeutic use

Substances

  • Anti-Infective Agents
  • Fluoroquinolones
  • Quinolones
  • Enrofloxacin
  • Ciprofloxacin
  • difloxacin
  • marbofloxacin