The Microenvironment of the Tumour-Host Interface

Nature. 2001 May 17;411(6835):375-9. doi: 10.1038/35077241.

Abstract

Throughout the entire process of cancer aetiology, progression and metastasis, the microenvironment of the local host tissue can be an active participant. Invasion occurs within a tumour-host microecology, where stroma and tumour cells exchange enzymes and cytokines that modify the local extracellular matrix, stimulate migration, and promote proliferation and survival. A new class of cancer therapies that targets this pathological communication interface between tumour cells and host cells is currently under development.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Cell Communication* / drug effects
  • Cell Division / drug effects
  • Cell Movement / drug effects
  • Cell Survival / drug effects
  • Humans
  • Neoplasm Metastasis / drug therapy
  • Neoplasms / drug therapy
  • Neoplasms / metabolism*
  • Neoplasms / pathology*
  • Oligonucleotide Array Sequence Analysis
  • Stromal Cells / cytology
  • Stromal Cells / drug effects
  • Stromal Cells / metabolism

Substances

  • Antineoplastic Agents