Interleukin-1 receptor antagonist treatment of rheumatoid arthritis patients: radiologic progression and correlation of Genant/Sharp and Larsen scoring methods

Semin Arthritis Rheum. 2001 Apr;30(5 Suppl 2):26-32. doi: 10.1053/sarh.2001.23697.


Objective: The Genant/Sharp scoring method is a validated radiologic scoring system useful for diagnosing, classifying, and defining specific clinical problems associated with rheumatoid arthritis (RA). The Genant/Sharp scoring method is described, and its level of correlation with the Larsen scoring method is discussed.

Method: The Genant/Sharp scoring system evaluates erosion, joint space narrowing (JSN), and a combination of erosion and JSN referred to as the total score. This method was used to determine change in radiographic progression during 2 consecutive 6-month intervals within a multicenter, double-blind, placebo-controlled study of recombinant human interleukin-1 receptor antagonist (IL-1ra) in patients with RA. These results were compared with the results obtained through the Larsen scoring method to determine their correlation.

Results: The Genant/Sharp scoring method showed a moderate correlation with the Larsen scoring method, particularly at baseline, and showed similar treatment trends in a study of IL-1ra in patients with RA.

Conclusion: The Genant/Sharp scoring method provides an alternative to the Sharp and Larsen approaches for radiographic assessment in RA.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Arthritis, Rheumatoid / diagnostic imaging*
  • Arthritis, Rheumatoid / drug therapy*
  • Arthrography*
  • Disease Progression
  • Double-Blind Method
  • Humans
  • Interleukin 1 Receptor Antagonist Protein
  • Recombinant Proteins / therapeutic use
  • Severity of Illness Index*
  • Sialoglycoproteins / therapeutic use*


  • IL1RN protein, human
  • Interleukin 1 Receptor Antagonist Protein
  • Recombinant Proteins
  • Sialoglycoproteins