Parkinson's disease is not associated with the combined alpha-synuclein/apolipoprotein E susceptibility genotype

Ann Neurol. 2001 May;49(5):665-8.


A recent study showed significant association of sporadic Parkinson's disease with a polymorphism within the alpha-synuclein gene and closely linked DNA markers on chromosome 4q and the APOE epsilon4 allele. A combined alpha-synuclein/APOE-epsilon4 genotype increased the relative risk of developing Parkinson's disease 12-fold. We failed to confirm this association in a much larger sample of histopathologically proven cases of Parkinson's disease and controls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Apolipoproteins E / genetics*
  • Chromosomes, Human, Pair 4 / genetics
  • Female
  • Genetic Markers / genetics
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Nerve Tissue Proteins / genetics*
  • Parkinson Disease / genetics*
  • Polymorphism, Genetic / genetics
  • Synucleins
  • alpha-Synuclein


  • Apolipoproteins E
  • Genetic Markers
  • Nerve Tissue Proteins
  • SNCA protein, human
  • Synucleins
  • alpha-Synuclein