T1 hypointensities and axonal loss

Neuroimaging Clin N Am. 2000 Nov;10(4):739-52 ,ix.


T1 hypointensities are lesions that are hypointense on moderately T1-weighted conventional spin-echo sequences and serve as markers of matrix destruction and axonal loss. They correlate better with clinical disability than T2-weighted images, are found in patients with progressive multiple sclerosis, and can be used as surrogate outcome measures in treatment trials.

Publication types

  • Review

MeSH terms

  • Axons / pathology
  • Brain / pathology
  • Diagnosis, Differential
  • Disability Evaluation
  • Echo-Planar Imaging
  • Humans
  • Image Enhancement
  • Magnetic Resonance Imaging*
  • Magnetic Resonance Spectroscopy
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / pathology
  • Multiple Sclerosis, Chronic Progressive / diagnosis
  • Multiple Sclerosis, Chronic Progressive / pathology
  • Retrograde Degeneration / diagnosis*
  • Retrograde Degeneration / pathology