[Angiotension I converting enzyme gene polymorphism in Chinese patients with obstructive sleep apnea syndrome]

Zhonghua Jie He He Hu Xi Za Zhi. 1998 Aug;21(8):489-91.
[Article in Chinese]


Objective: To investigate the relationship of an insertion/deletion (I/D) polymorphism of the angiotension-converting enzyme (ACE) gene to obstructive sleep apnea syndrome (OSAS).

Method: Genomic DNA was extracted from blood samples and amplified by polymerase chain reaction (PCR). PCR primers were flanking the polymorphic region in intron 16 of the ACE gene.

Result: The distribution of the DD, ID, and II ACE genotypes was 16%, 52%, and 32% in the control subjects and 0%, 56%, and 44% in OSAS patients, respectively. The estimated frequencies of the insertion allele and the deletion allele were 58%, 42% in the control subjects and 72%, 28% in OSAS patients, respectively. The differences were statistically significant(P < 0.05). The OSAS patients with I/I genotype had significantly longer apnea time (P < 0.05), lower minimum SaO2(P < 0.05) and more severe AHI (P < 0.05) than did the OSAS patients with I/D genotype.

Conclusion: These results indicate that the II genotype and I allele might be a risk factor for OSAS in Chinese.

Publication types

  • English Abstract

MeSH terms

  • Alleles
  • Asian Continental Ancestry Group
  • Female
  • Gene Frequency
  • Humans
  • Hypertension / complications
  • Hypertension / genetics
  • Male
  • Peptidyl-Dipeptidase A / genetics*
  • Polymorphism, Genetic
  • Risk Factors
  • Sleep Apnea, Obstructive / complications
  • Sleep Apnea, Obstructive / enzymology
  • Sleep Apnea, Obstructive / genetics*


  • Peptidyl-Dipeptidase A