[Research on immunological activity of non-immunological cells of decidua in normal early pregnancy]

Zhonghua Fu Chan Ke Za Zhi. 1999 Sep;34(9):533-5.
[Article in Chinese]

Abstract

Objectives: To investigate the immunological activity of non-immunological cells of decidua in normal early pregnancy.

Methods: Harvest the supernatant from cultured non-immunological cells of decidua. Inspect the effects of the supernatant on transforming function of T cells, killing activity of natural killer cells, the IgG secretion of B cells and the interleukin-2 (IL-2) secretion by lymphocytes of human peripheral blood by radioimmunological assay (RIA).

Results: The supernatant of the cultured non-immunological cells of decidua can inhibit the immunological function of T cells, natural killer cells and B cells to different extents, their maximum inhibiting ratio were 22.7%, 52.3% and 14.8% respectively, but there is no significant effect on the IL-2 secretion by lymphocytes.

Conclusions: The non-immunological cells of decidua in normal early pregnancy have immunological inhibiting function, which might contribute to prevent fetus from being expelled by maternal immunological system.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Decidua / cytology
  • Decidua / immunology*
  • Female
  • Humans
  • Immunoglobulin G / metabolism
  • Interleukin-2 / metabolism
  • Killer Cells, Natural / immunology
  • Lymphocyte Activation
  • Lymphocytes / cytology
  • Lymphocytes / immunology*
  • Pregnancy
  • Pregnancy Trimester, First

Substances

  • Immunoglobulin G
  • Interleukin-2