[Effects of prepartum infusion solutions on glucose and bilirubin metabolism of mother and child in the prepartum and postpartum period]

Z Geburtshilfe Neonatol. 2001 Mar-Apr;205(2):60-4. doi: 10.1055/s-2001-14822.
[Article in German]

Abstract

Background: Administration of glucose 5% infusion is regularly used in obstetrics. The purpose of the study was to investigate the effects of glucose as compared to xylose and electrolyte solutions on parameters of maternal and fetal glucose and bilirubin metabolism during labour and after delivery.

Patients and methods: 53 pregnant women (> or = 37 weeks of gestation, uncomplicated pregnancies) were randomised by entering the delivery ward. Under labour either glucose 5%, xylose 5% or electrolyte infusions were administered. Maternal serum glucose, serum osmolarity, insulin and glucagon were analysed before administration and 20 minutes after delivery. In the newborn blood osmolarity and serum glucose levels were analysed in the umbilical cord directly after birth and in capillary blood samplings 2 hours after birth.

Results: Maternal blood glucose levels 20 min. post partum were significantly different (p < 0.05). Maternal insulin and glucagon concentrations 20 min. pp showed similar trends with glucose levels but were not significantly different. Glucose levels in the umbilical cord were significantly higher in the glucose than in the electrolyte group, but not higher than in the Xylit group. In contrast, the glucose-levels in the newborns after 2 h were significantly higher in the glucose group compared with both other groups. No significant differences were observed in bilirubin levels. Osmolarity in the umbilical cord between groups differed significantly.

Conclusions and discussion: In conclusion, the administration of different solutions showed a distinct influence on the maternal and neonatal glucose metabolism. A significant impact on the bilirubin levels could not be shown in this study.

Publication types

  • Clinical Trial
  • Comparative Study
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Bilirubin / blood*
  • Blood Glucose / metabolism*
  • Contrast Media / administration & dosage
  • Female
  • Fetal Blood / metabolism
  • Fluid Therapy*
  • Glucose Solution, Hypertonic / administration & dosage*
  • Glucose Solution, Hypertonic / adverse effects
  • Humans
  • Infant, Newborn
  • Insulin / blood
  • Labor, Obstetric / physiology*
  • Maternal-Fetal Exchange / physiology*
  • Organic Chemicals
  • Pregnancy

Substances

  • Blood Glucose
  • Contrast Media
  • Glucose Solution, Hypertonic
  • Insulin
  • Organic Chemicals
  • sterofundin
  • Bilirubin