Virologic failure and salvage therapy

HIV Hotline. 1998 Mar;8(1):2-3.


AIDS: Researchers indicate that virologic failure during protease inhibitor (PI) therapy does not equate to clinical failure, and several studies reveal hopeful data on salvage therapy. One study suggests that salvage therapy after nelfinavir failure may be feasible with ritonavir/saquinavir. Other studies are showing that limited efficacy of ritonavir/saquinavir after failure of indinavir may be associated with a delay in switching to salvage therapy. Finally, some studies have shown that 9 of 12 patients who have failed multiple therapies, but were naive to nelfinavir and nevirapine and treated with d4T, ddI, 3TC, nevirapine, nelfinavir, and saquinavir, achieved undetectable viral load at 12 weeks.

Publication types

  • Newspaper Article

MeSH terms

  • Anti-HIV Agents / administration & dosage
  • Anti-HIV Agents / therapeutic use*
  • CD4 Lymphocyte Count
  • Drug Therapy, Combination
  • HIV Infections / drug therapy*
  • HIV Infections / virology
  • HIV Protease Inhibitors / administration & dosage
  • HIV Protease Inhibitors / therapeutic use*
  • Humans
  • Salvage Therapy
  • Treatment Failure
  • Viral Load


  • Anti-HIV Agents
  • HIV Protease Inhibitors