Viagra warning re "poppers" and notice re protease inhibitors

AIDS Treat News. 1998 May 1:(No 294):1.

Abstract

AIDS: Pfizer, Inc., manufacturer of Viagra (sildenafil), is warning patients that Viagra is contraindicated with nitrate inhalers (poppers). Nitrates in any form or nitric oxide donors can potentially cause hypotension. Pfizer also recommends that patients using protease inhibitors, particularly ritonavir, use a lower dose of Viagra (25 mg) because they interfere with the elimination of Viagra. This interaction does not pose a significant risk to the patient.

Publication types

  • Newspaper Article

MeSH terms

  • Amyl Nitrite / adverse effects*
  • Cytochrome P-450 Enzyme System / metabolism
  • Drug Interactions
  • Enzyme Inhibitors / adverse effects*
  • Enzyme Inhibitors / metabolism
  • HIV Protease Inhibitors / metabolism
  • Humans
  • Hypotension / chemically induced*
  • Male
  • Piperazines / adverse effects*
  • Piperazines / metabolism
  • Purines
  • Sildenafil Citrate
  • Sulfones
  • Vasodilator Agents / adverse effects*

Substances

  • Enzyme Inhibitors
  • HIV Protease Inhibitors
  • Piperazines
  • Purines
  • Sulfones
  • Vasodilator Agents
  • Amyl Nitrite
  • Cytochrome P-450 Enzyme System
  • Sildenafil Citrate