Percutaneous treatment of chronic MRSA osteomyelitis with a novel plant-derived antiseptic

BMC Surg. 2001;1:1. doi: 10.1186/1471-2482-1-1. Epub 2001 May 16.


Background: Antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE, are an increasing problem world-wide, causing intractable wound infections. Complex phytochemical extracts such as tea tree oil and eucalypt-derived formulations have been shown to have strong bactericidal activity against MRSA in vitro. Polytoxinol (PT) antimicrobial, is the trade name of a range of antimicrobial preparations in solution, ointment and cream form.

Methods: We report the first use of this drug, administered percutaneously, via calcium sulphate pellets (Osteoset,TM), into bone, to treat an intractable MRSA infection of the lower tibia in an adult male.

Results and discussion: Over a three month period his symptoms resolved with a healing response on x-ray and with a reduced CRP.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / therapeutic use
  • Drug Combinations
  • Drug Implants
  • Eucalyptus
  • Humans
  • Male
  • Methicillin Resistance
  • Middle Aged
  • Monoterpenes / administration & dosage*
  • Monoterpenes / therapeutic use
  • Oils, Volatile / administration & dosage*
  • Oils, Volatile / therapeutic use
  • Osteomyelitis / drug therapy
  • Osteomyelitis / microbiology*
  • Phytotherapy*
  • Plant Preparations / administration & dosage*
  • Plant Preparations / therapeutic use
  • Staphylococcal Infections / drug therapy*
  • Staphylococcus aureus / drug effects
  • Tea Tree Oil / administration & dosage*
  • Tea Tree Oil / therapeutic use


  • Anti-Bacterial Agents
  • Drug Combinations
  • Drug Implants
  • Monoterpenes
  • Oils, Volatile
  • Plant Preparations
  • Tea Tree Oil
  • ingalipt