Cancer screening in a high risk population: a clinical trial

Ultrasound Med Biol. 2001 Apr;27(4):461-6. doi: 10.1016/s0301-5629(00)00359-8.


The purpose of this paper is to report the results of screening high risk women for ovarian cancer using endovaginal ultrasound (EVUS), color flow Doppler and cancer antigen (CA) 125. A total of 252 women were recruited with a family history of ovarian cancer in at least 1 first-degree relative. All women underwent a pelvic examination and EVUS twice during the first year and annually thereafter. Of 210 premenopausal women in the study, 14 underwent surgery. Of these, 2 were based on the endovaginal ultrasound (US) results and proved to be false-positive. There were 48 postmenopausal women who underwent 9 operations. Of these, 2 were stimulated by finding a thickened stripe on EVUS, and proved to be endometrial carcinomas. There were 2 ovarian cancers, both advanced, 1 colon cancer and 1 renal cell cancer. Of the women, 6 had a history of breast cancer and 11 more developed it during the study. This high-risk population has a very high prevalence of breast cancer, and mammography must be a part of ovarian cancer screening programs.

MeSH terms

  • Adult
  • Biomarkers, Tumor / analysis
  • Blood Flow Velocity
  • CA-125 Antigen / blood
  • Endometrial Neoplasms / diagnostic imaging
  • Female
  • Humans
  • Middle Aged
  • Ovarian Neoplasms / blood supply
  • Ovarian Neoplasms / diagnosis
  • Ovarian Neoplasms / diagnostic imaging*
  • Ovarian Neoplasms / genetics
  • Ovary / blood supply
  • Risk Factors
  • Tomography, X-Ray Computed
  • Ultrasonography, Doppler
  • Uterine Neoplasms / diagnostic imaging


  • Biomarkers, Tumor
  • CA-125 Antigen